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细胞核存在由钙相关受体和通道组成的独立钙信号调节系统,细胞核钙信号参与了细胞的增殖、分化、凋亡等生理及病理过程,对细胞核钙信号的来源、核钙与胞浆钙的关系、核钙信号与基因转录、凋亡等关系的研究为细胞生理功能及细胞病理学提供了极有价值的资料,为解决一些重大的医学难题如肿瘤、阿尔茨海默病、心脏病和艾滋病等提供崭新的视角和手段。
In the nucleus, an independent calcium signaling system composed of calcium-related receptors and channels exists. The nuclear calcium signals are involved in the physiological and pathological processes such as cell proliferation, differentiation and apoptosis. The effects of nuclear calcium signal and cytoplasmic calcium The relationship between nuclear calcium signaling and gene transcription and apoptosis has provided valuable information on cellular physiology and cytopathology. In order to solve some major medical problems such as cancer, Alzheimer’s disease, heart disease and AIDS and provide a new perspective and means.