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目的：实验观察油酸型急性肺水肿家兔血浆纤维连接蛋白（Ｆｎ）和肺表面活性物质（ＰＳ）含量的变化，以及给予山莨菪碱（６５４－２）后对其变化的影响。方法：家兔４０只分４组。采用静脉注射油酸０．１２ｍｌ·ｋｇ－１复制油酸型肺水肿模型，预防组和治疗组在注油酸前、后分别给予６５４－２１０ｍｇ·ｋｇ－１，ｉｖ。其它组给予生理盐水对照。结果：肺水肿组血浆Ｆｎ含量明显减少，肺组织匀浆ＰＳ含量亦明显减少。肺损伤前给予６５４－２，可阻止血浆Ｆｎ及ＰＳ的减少。结论：血浆Ｆｎ含量不足使肺毛细血管膜受损，血管通透性增高，引发或加重了肺水肿，６５４－２能阻止这一过程，从而减轻肺水肿的发生发展。
OBJECTIVE: To observe the changes of Fn and PS in rabbits with oleic acid-induced acute pulmonary edema and the effect of anisodamine (654-2) on the changes of Fn and PS. Methods: 40 rabbits were divided into 4 groups. The models of oleic acid-induced pulmonary edema were reproduced by intravenous injection of oleic acid 0.12ml · kg-1. The preventive and treatment groups were given 654-210mg · kg-1, iv before and after oleic acid injection respectively. The other groups were given saline control. Results: Plasma Fn levels were significantly decreased in pulmonary edema group and PS content in lung homogenate was also significantly decreased. Given before the lung injury 654-2, can prevent the decrease of plasma Fn and PS. CONCLUSION: Insufficient plasma Fn causes impaired pulmonary capillary membrane and increased vascular permeability, inducing or exacerbating pulmonary edema. 654-2 can prevent this process and thus reduce the occurrence and development of pulmonary edema.