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评价国产ｃｌａｒｉｔｈｒｏｍｙｃｉｎ（ＣＲＭ）对临床分离到的４６４株致病菌的体外抗菌作用，并与红霉素（ＥＭ）、麦迪霉素（ＭＤＭ）、麦白霉素（ＭＬＭ）、柱晶白霉素（吉他霉素，ＬＵＭ）进行比较。结果表明ＣＲＭ对ＥＭ敏感的金葡球菌、表葡球菌、肺炎链球菌和化脓链球菌的抗菌作用优于ＥＭ，明显优于其它３种同类对照药，ＭＩＣ（９０）为０．０６２～２ｍｇ／Ｌ；对部分ＥＭ耐药的表葡球茵，化脓链球菌和粪链球菌也有一定的抗菌作用；对流感嗜血杆菌和对ＥＭ敏感的粪链球菌的抗菌作用同ＥＭ，优于其它３种同类对照药，ＭＩＣ_（９０）为０．５～２ｍｇ／Ｌ；对部分厌氧菌也有一定的抗菌作用，细菌接种量对ＣＲＭ的抗菌作用有一定的影响，但仍在敏感范围之中；ｐＨ值的变化影响ＣＲＭ抗菌作用，其抗菌作用在碱性条件下较强，尤以ｐＨ８．５时为显著；少量的人血清不影响ＣＲＭ的抗菌作用，但浓度加至７５％，ＣＲＭ的抗菌作用减弱。
To evaluate the in vitro antibacterial activity of domestic clarithromycin (CRM) against 464 pathogenic bacteria isolated from clinical isolates, and to evaluate the antimicrobial activity of domestic clarithromycin (CRM) against erythromycin (EM), midecamycin (MDM), melemomycin (Guitarmycin, LUM) for comparison. The results showed that the antibacterial activity of CRM against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae and Streptococcus pyogenes was superior to that of EM, which was significantly superior to the other three kinds of similar control drugs. MIC (90) was 0.062 ~ 2mg / L; some of the drug-resistant strains of E. coli, Streptococcus pyogenes and Streptococcus faecalis also have some antibacterial effect; Haemophilus influenzae and EM-sensitive Streptococcus faecalis with EM, better than the other three The MIC (90) is 0.5 ~ 2mg / L for the same kind of control drug. Some anaerobic bacteria also have certain antibacterial effect. Inoculation amount of bacteria has some influence on the antibacterial activity of CRM, but it is still in the sensitive range. PH The change of the value affected the antibacterial effect of CRM, and its antibacterial activity was stronger under alkaline conditions, especially at pH 8.5; a small amount of human serum did not affect the antibacterial effect of CRM, but the antibacterial effect of CRM was increased at a concentration of 75% Weakened.