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目的 :探讨女性甲状腺功能异常患者血清瘦素 (Leptin)水平的变化。方法 :采用放射免疫分析法 (RIA)分别检测 6 0例甲状腺功能亢进、36例原发性甲状腺功能减退和 30例健康人血清Leptin水平 ,并随访经过治疗后甲状腺功能恢复至正常水平患者 (2 4例甲亢、12例甲减 )血清Leptin水平。结果 :各组Leptin水平皆与BMI呈强正相关 (p <0 0 1)。Leptin水平 (甲减组 4 2 1± 1 87μg/L)明显低于健康组 (8 18± 3 31μg/L) ,有统计学意义 (p <0 0 1) ;甲亢组 8 6 1± 3 0 4 μg/L与健康组比较无显著性差异 (p >0 0 5 )。治疗后甲减缓解组Leptin水平 (6 77± 2 35 μg/L)明显高于初诊未治疗组 (4 19± 1 84 μg/L) (p <0 0 5 ) ,接近正常人水平 ;甲亢组治疗前后Leptin水平无明显差异 (p >0 0 5 )。结论 :生理剂量的甲状腺激素可使人体产生足够的Leptin ,维持人体的正常能量代谢。甲状腺功能异常因甲状腺激素的变化而影响了Leptin的正常调节。
Objective: To investigate the changes of serum leptin levels in female patients with thyroid dysfunction. Methods: Sixty cases of hyperthyroidism, 36 cases of primary hypothyroidism and 30 cases of healthy people were detected by radioimmunoassay (RIA). Serum Leptin level was detected in 30 healthy people after follow-up, and thyroid function recovered to normal level 4 cases of hyperthyroidism, 12 cases of hypothyroidism) serum Leptin levels. Results: Leptin levels in each group were positively correlated with BMI (p <0.01). The level of Leptin in the hyperthyroidism group (42 ± 1 87 μg / L) was significantly lower than that in the healthy group (8 18 ± 3 31 μg / L), with a significant difference (p <0.01) 4 μg / L compared with the healthy group no significant difference (p> 0.05). The level of Leptin (6 77 ± 2 35 μg / L) in the treatment group was significantly higher than that of the untreated group (4 19 ± 1 84 μg / L) (p 0 05), which was close to the normal level. The hyperthyroidism group Leptin levels before and after treatment had no significant difference (p> 0.05). Conclusion: Physiological dose of thyroid hormone can make the body produce enough Leptin, to maintain the body’s normal energy metabolism. Thyroid dysfunction due to changes in thyroid hormone affect the normal regulation of Leptin.