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肝癌是最常见的人类恶性肿瘤之一.肝癌的发生是一个多因素交互作用逐级发生的过程.包括乙肝、丙肝病毒感染、酗酒、肝硬化等都可能导致肝癌.研究表明,胰岛素样生长因子(IGF)系统由IGF1、IGF2及其受体(IGF1R、IGF2R)和胰岛素样生长因子结合蛋白(IGFBP)组成,在正常以及恶性肝细胞的增殖、分化和转移过程中起重要作用.本综述回顾近年来胰岛素样生长因子系统与肝癌发生发展的机理研究,及其在肝癌治疗中可能的临床应用前景的研究进展,并对目前该研究领域存在的主要问题和未来的研究展望提出了看法.
Liver cancer is one of the most common human malignancies. The occurrence of liver cancer is a multi-factorial interaction step by step process, including hepatitis B, hepatitis C virus infection, alcoholism, cirrhosis and so may lead to liver cancer.Studies show that insulin-like growth factor (IGF) system consists of IGF1, IGF2 and its receptors (IGF1R, IGF2R) and insulin-like growth factor binding protein (IGFBP) and plays an important role in the proliferation, differentiation and metastasis of normal and malignant hepatocytes. In recent years, the mechanism of insulin-like growth factor system and hepatocellular carcinoma (HCC) development and its possible clinical application prospect in the treatment of hepatocellular carcinoma (HCC) are reviewed. The main problems and future research prospects in this field are also discussed.