急淋患者中枢神经系统和睾丸白血病的预防和治疗

• 作 者: 沈志祥 陈淑蓉
• 机 构: 上海市瑞金医院内科血液组,上海市瑞金医院内科血液组
• 出 处: 国外医学(肿瘤学分册)
• 发表日期: 1986年05期
• 关键词: 睾丸白血病 急淋 中枢神经系统 白血病发生 颅脑放疗 白血病复发 诱导缓解 骨髓缓解 药物化疗 淋巴结病变

最近几年,随着各种新型的抗白血病药物的问世及化疗方案的应用,90%左右的急性淋巴细胞性白血病(ALL)患者可获完全缓解,但在长期存活的ALL患者中约有半数复发,其中白血病的髓外病灶是复发的重要原因之一。中枢神经系统(CNS)和睾丸是二个最主要的白血病的髓外病灶,因此CNS和睾丸白血病的预防和治疗已成为提高ALL治愈率的关键之一,目前国外学者对此进行了大量研究,本文就近年来研究进展作一简单的文献复习。

In recent years, with the advent of a variety of new anti-leukemia drugs and chemotherapy applications, about 90% of patients with acute lymphoblastic leukemia (ALL) can be completely relieved, but about half of ALL patients with long-term survival Recurrence, including leukemia extramedullary lesions is one of the important reasons for recurrence. Central nervous system (CNS) and testis are two of the most important leukemia extramedullary lesions, so the prevention and treatment of CNS and testicular leukemia has become one of the keys to improve the cure rate of ALL. At present, foreign scholars have done a lot of research, This article makes a brief review on the research progress in recent years.