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AIM:To study the liver and spleen volume variations in hepatic fibrosis patients at different histopathological stages.METHODS:Multidetector computed tomography (MDCT) scan was performed in 85 hepatic fibrosis patients.Liver volume (LV) and spleen volume (SV) were measured.Fifteen healthy individuals served as a control group (S0).The patients were divided into stage 1 (S1) group (n=34),stage 2 (S2) group (n=25),stage 3 (S3) group (n=16),and stage 4 (S4) group (n=10) according to their histopathological stage of liver fibrosis.RESULTS:The LV and standard LV(SLV)had a tendency to increase with the severity of fibrosis,but no statistical difference was observed in the 5 groups (LV:F=0.245,P=0.912;SLV:F=1.902,P =0.116).The SV was gradually increased with the severity of fibrosis,and a statistically significant difference in SV was observed among the 5 groups (P < 0.01).The LV/SV ratio and SLV/SV ratio were gradually decreased with the aggravation of hepatic fibrosis,and statistically significant differences in both LV/SV and SLV/SV were found among the 5 groups (P < 0.01).CONCLUSION:The absence of obvious LV reduction in patients with chronic liver disease may be a morphological index of patients without liver cirrhosis.The SV is related to the severity of fibrosis,and the spleen of patients with advanced fibrosis is enlarged evidently.The LV/SV ratio and SLV/SV ratio are of a significant clinical value in the diagnosis of advanced liver fibrosis.
AIM: To study the liver and spleen volume variations in hepatic fibrosis patients at different histopathological stages. METHODS: Multidetector computed tomography (MDCT) scan was performed in 85 hepatic fibrosis patients. Liver volume (LV) and spleen volume (SV) were measured. The fifteen healthy individuals served as a control group (S0). The patients were divided into stages 1 (S1) group (n = 34), stage 2 (S2) group 16), and stage 4 (S4) group (n = 10) according to their histopathological stage of liver fibrosis .RESULTS: The LV and standard LV (SLV) had a tendency to increase with the severity of fibrosis, but no statistical difference was observed in the 5 groups (LV: F = 0.245, P = 0.912; SLV: F = 1.902, P = 0.116). The SV was gradually increased with the severity of fibrosis, and a significant difference in SV was observed among the 5 groups (P <0.01). The LV / SV ratio and SLV / SV ratio were gradually decreased with the aggravation of hepatic fibrosis, and indicative The absence of obvious LV reduction in patients with chronic liver disease may be a morphological index of patients without liver cirrhosis.The SV is related to the severity of fibrosis, and the spleen of patients with advanced fibrosis is enlarged evidently. LV / SV ratio and SLV / SV ratio are of a significant clinical value in the diagnosis of advanced liver fibrosis.