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目的观察琥珀酸普卢卡必利联合乳果糖治疗老年难治性便秘(IC)的疗效。方法36例老年IC患者给予琥珀酸普卢卡必利(口服2mg/d)联合乳果糖(口服每次15ml,每日3次)治疗,疗程4周,观察治疗前后每周自主排便次数,48、72h胃肠道排空率及药物不良反应。结果治疗后患者每周自主排便次数多于治疗前(P<0.05),自主排便次数≥3次/周者比例高于治疗前(61.11%vs.22.22%)(P<0.05),48、72h胃肠道排空率分别为(75.00±10.69)%、(86.88±6.51)%,均高于治疗前的(54.37±8.63)%、(70.75±2.18)%(P<0.05)。4例出现不良反应后均缓解。结论琥珀酸普卢卡必利联合乳果糖能有效改善老年IC患者症状,不良反应少,安全有效。
Objective To observe the curative effect of prucalopride succinate combined with lactulose in the treatment of elderly patients with refractory constipation (IC). Methods 36 elderly patients with IC were given prucalopride succinate (oral 2mg / d) combined with lactulose (oral 15ml three times daily) for 4 weeks. The number of spontaneous bowel movements per week before and after treatment was observed. , 72h gastrointestinal emptying rate and adverse drug reactions. Results After treatment, the number of spontaneous bowel movements per week was higher than that before treatment (P <0.05), and the number of spontaneous bowel movements ≥3 times per week was higher than that before treatment (61.11% vs.22.22%) (P <0.05) Gastrointestinal emptying rate was (75.00 ± 10.69)% and (86.88 ± 6.51)%, respectively, which were higher than those before treatment (54.37 ± 8.63)% and (70.75 ± 2.18)%, respectively. 4 cases were adverse reactions were relieved. Conclusions Prucalopride succinate combined with lactulose can effectively improve the symptoms of elderly IC patients with less adverse reactions and is safe and effective.