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作者测定垂体机能减退患者的总高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)及总胆固醇(TC)水平。男10例,女3例。其中10例在激素替代疗法前受检,余3例在检查前停止治疗至少4周。病人的肾功能均正常,仅1例女性有轻微的肝功能损害。附加6例无明显糖尿病病人中3例男性患孤立的下丘脑不足综合征(例14～16),3例患活动性肢端肥大症(例17～19)也作脂类测定。对照组包括40名正常男性(年龄20～82岁,平均39岁)和20名正常女性(年龄18～33岁,平均24.8岁)。结果垂体机能减退的男女患者,平均TC和TG水平与对照组相比均显著增高,但其中仅5例TG水平升高>150mg/dl,4例胆固醇水平>250mg/dl。垂体机能减退未治者与对照组相比HDL-C水平显著较低(P<0.01)。个体的HDL-C值无1例在正常范围。1例患孤立的GH不足男性HCL C浓度和HDL-C与TC比率均低。2例Eallman’s综合征患者中1例HDL-C浓度正常,而另1例(例16)浓度虽然最低限度地降低,但比垂体机能减退者较高。1例男性肢端肥大症患者数值正常,而另2例胆固醇浓
The authors measured total high density lipoprotein cholesterol (HDL-C), triglyceride (TG) and total cholesterol (TC) levels in patients with hypopituitarism. 10 males and 3 females. Of these, 10 were tested before hormone replacement therapy and the remaining 3 were stopped for at least 4 weeks prior to the test. The patient’s renal function are normal, only 1 case of women have mild liver damage. Three additional men with no obvious diabetes mellitus developed isolated hypothalamic syndrome (cases 14-16) and three had active acromegaly (cases 17-19). The control group consisted of 40 normal men (aged 20-82 years, mean 39 years) and 20 normal women (aged 18-33 years, mean 24.8 years). Results The average TC and TG levels of both male and female patients with hypopituitarism were significantly higher than those of the control group. However, only 5 cases had elevated TG levels> 150 mg / dl and 4 cases had cholesterol levels> 250 mg / dl. Compared with control group, HDL-C level in hypopituitarism was significantly lower (P <0.01). None of the individuals had HDL-C values in the normal range. One patient with isolated GH deficiency had lower HCL C concentrations and lower HDL-C to TC ratios. One of 2 patients with Eallman’s syndrome had normal HDL-C concentration, whereas the other (Example 16) had a lower concentration than the pituitary dysfunction, although the concentration was minimal. One case of acromegaly had normal values and the other two had high levels of cholesterol