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本文比较性研究甲基黄酮醇胺盐酸盐（ＭＦＡ），三氟拉嗪（Ｔｒｉ），维拉帕米（Ｖｅｒ），氨茶碱（Ａｍｉ）和异丙肾上腺素（Ｉｓｏ）对豚鼠离体气管的舒张作用．ＭＦＡ（０．１－０．３ｍｍｏｌ·Ｌ－１）时间依赖性舒张ＫＣｌ诱导的气管平滑肌收缩。低于０．１ｍｍｏｌ·Ｌ－１时ＭＦＡ对ＫＣｌ诱导的收缩仅有轻微作用，却使Ｉｓｏ和Ａｍｉ的浓度舒张曲线明显向左上移动。ＭＦＡ，Ｖｅｒ，Ｔｒｉ使ＣａＣｌ２量效曲线向右下移，ｐＤ２值分别为：５．０±ｓ０．５，６．４±ｓ０．８，５．０±ｓ０．６．ＭＦＡ，Ｖｅｒ，Ｔｒｉ，Ａｍｉ剂量依赖性抑制次大量生理激动剂所致的收缩，其作用强度顺序为：Ｔｒｉ＞Ｖｅｒ＝ＭＦＡ＞Ａｍｉ．提示ＭＦＡ具有非竞争性钙拮抗作用，其作用方式与Ｔｒｉ相似。与Ａｍｉ相比、ＭＦＡ是一个较强的主气管扩张剂，并与Ａｍｉ，Ｉｓｏ具有明显的协同舒张支气管作用。
In this study, we compared the effects of MFA, Tri, Ver, Ami and Iso on guinea pig in vitro Tracheal relaxation. MFA (0.1-0.3 mmol·L-1) diastolic KCl-induced tracheal smooth muscle contraction in a time-dependent manner. Below 0.1 mmol·L-1, MFA had only a slight effect on KCl-induced contraction, leaving the concentration-dependent relaxation curve of Iso and Ami to move up to the left. MFA, Ver, Tri make CaCl2 dose-effect curve down to the right, pD2 values were: 5.0 ± s0.5,6.4 ± s0.8,5.0 ± s0.6. MFA, Ver, Tri, and Ami dose-dependently inhibited the contraction induced by a large number of physiological agonists in the order of Tri> Ver = MFA> Ami. Suggesting that MFA has a noncompetitive calcium antagonism and its mode of action is similar to that of Tri. Compared with Ami, MFA is a stronger main tracheal dilator and has obvious synergistic relaxation bronchial function with Ami, Iso.