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毛细管电泳在线富集技术具有灵敏度高、操作简单、成本低廉、试剂消耗少等特点,主要包括等速电泳、电堆积富集、扫集法、pH调制堆积和在柱色谱预浓缩等,这些方法可以提高检测灵敏度,降低样品浓度检测限,拓展毛细管电泳在众多领域的应用。本文综述了近年来毛细管电泳在线富集技术在生物样品中痕量药物分析的应用及研究进展。
Capillary electrophoresis online enrichment technology has the characteristics of high sensitivity, simple operation, low cost, low reagent consumption, etc. These methods include isokinetic electrophoresis, electroplate enrichment, sweep collection, pH modulation and preconcentration in column chromatography Can improve the detection sensitivity, reduce the detection limit of sample concentration, and expand the application of capillary electrophoresis in many fields. This review summarizes the application and research progress of trace-level drug analysis in biological samples by capillary electrophoresis with on-line enrichment in recent years.