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为了改善HA纳米粒子与有机PLGA的相容性,分别采用六亚甲基二异氰酸酯加乙二醇、左旋乳酸改性纳米粒子表面后或直接原位接枝聚合左旋丙交酯等3种不同方法,制备了表面修饰聚乳酸的纳米羟基磷灰石(PLLA-g-HA).FTIR、XPS、TEM、TGA测试表明PLLA成功接枝到HA的表面.其中六亚甲基二异氰酸酯加乙二醇改性HA纳米粒子所获得的PLLA接枝率远高于其它两种方法达25%,调整有机相和无机相的比例对PLLA接枝率的影响较小,其在氯仿中可以稳定分散2天以上.共混电纺丝后的拉伸测试表明PLLA-g-HA/PLAG复合纤维膜的力学性能高于HA/PLGA膜,当两者之间的比例为5%拉伸性能达到最大值.
In order to improve the compatibility of HA nanoparticle with organic PLGA, three different methods, such as hexamethylene diisocyanate and ethylene glycol, L-lactic acid modified nanoparticles, or direct in-situ graft polymerization of L-lactide (PLLA-g-HA) with surface modification of polylactic acid was prepared.The results of FTIR, XPS, TEM and TGA showed that PLLA was successfully grafted onto the surface of HA.Among them, hexamethylene diisocyanate and ethylene glycol The PLLA grafting rate obtained by modified HA nanoparticles is much higher than that of the other two methods by 25%. Adjusting the proportion of organic phase and inorganic phase has little effect on the grafting yield of PLLA. It can be stably dispersed in chloroform for 2 days .The tensile test after blending electrospinning showed that the mechanical properties of PLLA-g-HA / PLAG composite fiber membrane were higher than that of HA / PLGA membrane, and the tensile properties of PLLA-g-HA /