如果至多只能有3个胚胎培养超过原核期,长时间胚胎培养会减少第4天和第5天的种植率

• 作 者: Montag M. Ven K.V.D. Dorn C. Ven H.V.D. 朱磊
• 机 构: Department of Gynecological Endocrinology and Reproductive Medicine University Clinics Bonn Sigmund-
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2006年04期
• 关键词: 胚胎培养 种植率 妊娠率 原核 天和 辅助生育 移植者 合子 方差分析 研究设计

Objectives: To study the potential of embryo transfer after 3, 4 or 5 days of embryo culture under the German embryo protection law according to which only a maximum of three zygotes are allowed to be cultured for embryo transfer. Study design: In a prospective study, 273 patients with assisted reproductive treatment were randomly allocated for transfer on days 3, 4 or 5. Pregnancy and implantation rates were evaluated in regard to day of transfer and results were compared by Chi-square or ANOVA test. Results: Out of 234 transfer cycles, 79 were performed on day 3, 76 on day 4 and 79 on day 5. Pregnancy and implantation rates were 41.8%/27.1%for transfer on day 3, 27.6%/14.1%for day 4 transfer and 16.5%/8.8%for transfer on day 5. These results were significantly different for pregnancy rates on day 3 versus day 5 (P < 0.001) and for implantation rates on day 3 versus day 4 (P < 0.005) and day 3 versus day 5 (P < 0.001). Conclusions: These findings suggest that extended embryo culture is not beneficial when the option for embryo selection at later stages of development is not available.

Objectives: To study the potential of embryo transfer after 3, 4 or 5 days of embryo culture under the German embryo protection law according to which only a maximum of three zygotes are allowed to be cultured for embryo transfer. Study design: In a prospective study , 273 patients with assisted reproductive treatment were randomly allocated for transfer on days 3, 4 or 5. Pregnancy and implantation rates were judged in day to day of transfer and results were compared by Chi-square or ANOVA test. Results: Out of 234 transfer cycles, 79 were performed on day 3, 76 on day 4 and 79 on day 5. Pregnancy and implantation rates were 41.8% / 27.1% for transfer on day 3, 27.6% / 14.1% for day 4 transfer and 16.5% / 8.8% for transfer on day 5. These results were significantly different for pregnancy rates on day 3 versus day 5 (P <0.001) and for shower rates on day 3 versus day 4 (P <0.005) and day 3 versus day 5 (P <0.001 Conclusions: These findings suggest that extended embryo culture i s not beneficial when the option for embryo selection at later stages of development is not available.