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目的探讨降钙素原对小儿重症感染的临床诊断价值,及其对于抗生素降阶梯治疗的指导作用。方法随机选取郑州市第一人民医院2011年4月—2013年11月期间收治的重症感染患儿60例、局部感染患儿60例及60例非感染组儿童,对其进行血清降钙素原及炎症因子检测,并根据检测结果对重症感染组患儿的抗生素治疗进行指导。结果重症感染组患儿的血清降钙素原及白细胞计数水平明显高于局部感染组及非感染组患儿,差异具有显著性(P<0.05)。结论症感染患儿早期血清降钙素原水平明显上升,可作为临床诊断的重要依据,同时在治疗过程中根据降钙素原水平的调整对降阶梯治疗进行指导,能够有效降低治疗成本,建议在临床上进一步推广。
Objective To investigate the clinical value of procalcitonin in the diagnosis of pediatric severe infection and its guiding role in the antibiotic-lowering therapy. Methods Sixty children with severe infection, 60 children with local infection and 60 non-infected children were randomly selected from Zhengzhou First People’s Hospital from April 2011 to November 2013. Serum procalcitonin And inflammatory cytokines, and according to the test results to guide the antibiotic treatment in children with severe infection. Results Serum procalcitonin and leukocyte counts in severe infection group were significantly higher than those in local infection group and non-infected group, the difference was significant (P <0.05). Conclusion Serum procalcitonin levels in children with congenital infection are significantly increased and can be used as an important basis for clinical diagnosis. At the same time, the treatment of descending steps can be guided according to the adjustment of procalcitonin level during treatment, which can effectively reduce the cost of treatment. In the clinical further promotion.