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作者分析200例骨髓增生性疾患(MPD)的骨髓活检的淋巴样小结的出现率。51例特发性骨髓纤维化(IM)中有12例,占23.5%;100例慢粒中仅2例(占2%);32例真性红细胞增生症中发现2例(占6%);17例特发性血小板增多症中出现1例(6%)。在IM与其余骨髓增生症之间的差别是显著的(P<0.0001),去除年龄关系之后P值仍为0.01。比较骨髓内有无淋巴样小结的临床、血液学和生化指标。有淋巴样小结者白细胞计数、血液中原始细胞及血清LDH均为显著低值。在IM各期中淋巴样小结的出现率分别为:纤维期(18例)中有7例;无骨化期(17例)中有4例;骨化期7例中仅1例。32例IM的细胞内免疫复合物检查:14例为阳性,有淋巴样小结的9例中7例阳性,无淋巴样小结的23例中7例
The authors analyzed the incidence of lymphoid nodules in a bone marrow biopsy of 200 cases of myeloproliferative disorders (MPD). Twelve cases (23.5%) were found in 51 cases of idiopathic myelofibrosis (IM), only 2 cases (2%) of 100 cases of chronic myelofibrosis and 2 cases (6%) of 32 cases of polycythemia vera; One case (6%) occurred in 17 cases of idiopathic thrombocythemia. The difference between IM and other myeloproliferative disorders was significant (P <0.0001), with a P value of 0.01 after removing the age-related relationship. Comparison of bone marrow with or without lymph node clinical, hematological and biochemical indicators. Lymphoid nodules white blood cell count, the blood of primitive cells and serum LDH were significantly lower. The incidence of lymphoid nodules in each stage of IM were 7 in fibronectomy (18 cases), 4 in non-ossification stage (17 cases), and 1 in 7 (7 cases) in ossification stage. 32 cases of IM intracellular immune complex examination: 14 cases were positive, lymphoid nodules in 9 cases, 7 cases were positive, no lymph node in 23 cases, 7 cases