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目的 探讨幽门螺杆菌 (HP)及感染细胞毒素相关蛋白基因A(CagA+ )亚型菌株在本地区健康成人人群中的感染情况。方法 对 2 68例健康成人血清先行HP筛查 ,对HP阳性的 165例的标本再用ELISA方法进行CagA -IgG抗体检测。结果 2 68例健康成人中HP阳性 165例 (62 %) ,其中女性HP感染率 69%(98/14 3 ) ,男性HP感染率 5 4%(67/12 5 ) ,两组比较差异有显著性意义(χ2 =6 2 84,P <0 0 5 )。CagA抗体阳性 91例 ,占HP阳性感染的 5 5 15 %;其中女性占HP感染的 61 2 4%,男性占HP感染的46 2 7%,两组比较统计学差异无显著性意义 (P >0 0 5 )。结论 广州地区健康成人感染HP达 62 %,其中 ,高致病性的CagA+ Ⅰ亚型菌株的感染率为 5 5 15 %;提示HP的防治工作不容忽视。
Objective To investigate the prevalence of Helicobacter pylori (HP) and the infection of CagA + subtype strains in healthy adult population in this area. Methods Two hundred seventy-six healthy adult sera were screened by HP, and 165 samples positive for HP were detected by ELISA for CagA-IgG antibody. Results Among 688 healthy adults, 165 were positive for HP (62%), of which 69% (98/14 3) were women with HP infection and 54% (67/12 5) were HP infection, with significant difference between the two groups Sexual significance (χ2 = 6 2 84, P <0 0 5). CagA antibody was positive in 91 cases, accounting for 55.15% of HP-positive infections. Among them, women accounted for 61.2% of HP infections and men accounted for 46.27% of HP infections. There was no significant difference between the two groups (P> 0 0 5). Conclusion In Guangzhou, the infection rate of HP reaches 62%. Among them, the infection rate of highly pathogenic CagA + Ⅰ subtype strains is 55.15%. It suggests that the prevention and cure of HP should not be neglected.