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目的 探讨高龄不孕患者行冻融胚胎移植对临床妊娠结局的影响.方法 回顾性分析在本中心接受体外受精-胚胎移植行冻融周期移植且年龄≥38岁的患者共计316个周期.根据患者年龄分为38-39岁组、40-42岁组和43-45岁组.比较3组患者行冻融周期移植的妊娠结局(临床妊娠率、种植率、流产率和抱婴率).结果 临床妊娠率3个年龄组比较有统计学差异(P＜0.05),两两比较38-39周岁组的临床妊娠率显著高于43-45周岁组(P＜0.05);种植率3个年龄组比较有统计学意义(P＜0.05),两两比较38-39周岁组的种植率极显著高于43-45周岁组(P＜0.01);流产率和抱婴率3个年龄组差异无统计学意义(P＞0.05).结论 随着患者年龄的增长,临床妊娠率和种植率开始下降,43周岁以后下降尤为明显.年龄≥38周岁的不孕女性尽早积极助孕治疗有助于改善其妊娠结局.“,”Objective:This study aimed to assess the clinical results following IVF in frozen-thawed embryos transfer (FET) in elder women.Methods:The patients underwent FET and age over 38 were collected f (316 cycles) in this study.Age was defined at the beginning of the ART and was divided into three groups:38-39,40-42 and 43-45 years old.Analysis the result of clinical pregnancy rate,embryos implantation rate,early abortion rate and delivery rates.Results:There was significant difference (P＜0.05) on clinical pregnancy rate and implantation rate in three different groups.The clinical pregnancy rate was higher in 38-39 group than 43-45 group (P＜0.05) and implantation rate was significantly different (P＜0.01) in 38-39 group compared to 43-45.There was no different in delivery rate and cumulative live birth rate (P＞0.05).Conclusions:The clinical pregnancy rate and implantation rate were start to decrease over 38 years old,espencially over 43 years old.It was important to improve the clinical results who using ART as soon as possible over 38 years old.