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在21条开胸狗心上,用微米狭窄器造成冠状动脉左旋支不同程度的狭窄。分别静注潘生丁(0.56mg/kg)。用创伤性方法检测用药前后左心室收缩功能的改变。轻度狭窄给予潘生丁后,LVDP 降低,CBF、dp/dtmax 和-dp/dtmax 有升高趋势,表明心功能改善。临界狭窄给予潘生丁后,LVDP 升高,而 CBF、LVSP、dp/dtmax、-dp/dtmax 均明显下降,表明心功进一步恶化。本实验可部分解释临床冠心病人做潘生丁试验所表现的不同结果,并为临床合理使用潘生丁提供了新的依据。
In the heart of 21 open-chest dogs, coronary stenosis caused by varying degrees of left-sided coronary artery stenosis with a micrometer stenosis. Pancreatin (0.56 mg / kg) was intravenously injected intravenously. Traumatic methods were used to detect changes in left ventricular systolic function before and after treatment. After mild stenosis given dipyridamole, LVDP decreased, CBF, dp / dtmax and-dp / dtmax increased, indicating that cardiac function improved. After the critical stenosis was given to dipyridamole, LVDP increased, while the CBF, LVSP, dp / dtmax, -dp / dtmax were significantly decreased, indicating further deterioration of cardiac function. This experiment can partly explain the different results of the clinical trial of dipyridamole in patients with coronary heart disease and provide a new basis for the clinical rational use of dipyridamole.