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目的:研究雷公藤红素(Tri)对胶原性关节炎的作用.方法:足肿测量仪测定足肿变化;酶联免疫吸附法测定血清抗胶原Ⅱ型抗体;皮肤迟发型变态反应水平测定;白细胞介素-2和白细胞介素-1的测定采用[~3H]TdR掺入法.对后足趾—跖关节作病理切片.结果:Tri 15和30 mg·kg~(-1)·d~(-1),发病3天后给药,改善足肿,抑制抗胶原Ⅱ型抗体水平和迟发型变态反应水平;抑制白细胞介素.1和白细胞介素-2产生;病理检查显示Tri明显抑制关节炎大鼠病理改变.结论:Tri对胶原性关节炎有治疗作用.
Objective: To study the effect of triptolide on collagenous arthritis.METHODS: The change of the foot swelling was measured by the foot swelling meter, the serum anti-collagen Ⅱ antibody was measured by enzyme-linked immunosorbent assay, the skin delayed type allergic reaction was measured, Interleukin-2 and interleukin-1 levels were measured by using [~ 3H] TdR incorporation method.Results: Tri 15 and 30 mg · kg -1 · d ~ (-1). After 3 days of onset, dorsal root swelling was observed, and the level of anti-collagen Ⅱ antibody and delayed-type allergic reaction were inhibited. The production of interleukin-1 and interleukin-2 were also inhibited. Arthritis rats pathological changes.Conclusion: Tri has a therapeutic effect on collagen-induced arthritis.