论文部分内容阅读
以硫脲为原料,经过两步反应合成三氧化硫脲(3);以N-甲基吡咯烷酮为原料,在HCl10%条件下水解生成4-甲基氨基丁酸盐酸盐(5);化合物(3)和(5)的亲核取代反应生成目标产物4-(1-甲基胍基)丁酸(6)。各中间体及目标产物结构经过红外光谱、核磁表征,结果表明,成功实现了目标产物的合成。抑菌实验表明,4-(1-甲基胍基)丁酸对金黄色葡萄球菌、大肠杆菌、啤酒酵母菌、黑曲霉的最低抑菌浓度分别为0.19%、0.195%、0.2%、0.19%。
Thiourea as the raw material, after two steps synthesis of thiourea dioxide (3); N- methylpyrrolidone as a raw material, under the conditions of HCl10% hydrolysis 4-methylaminobutyric acid hydrochloride (5); compound The nucleophilic substitution reaction of (3) and (5) yields the target product 4- (1-methylguanidino) butanoic acid (6). The structure of each intermediate and the target product was characterized by IR and NMR. The results showed that the target product was successfully synthesized. Bacteriostasis experiments showed that the minimum inhibitory concentrations of 4- (1-methylguanidino) butanoic acid on Staphylococcus aureus, Escherichia coli, Saccharomyces cerevisiae, Aspergillus niger were 0.19%, 0.195%, 0.2%, 0.19% .