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目的探讨Alpha B-crystallin在肺鳞状细胞癌组织中的表达及其意义。方法通过RT-PCR方法检测44例肺鳞状细胞癌患者癌组织中及其癌旁相对正常组织中Alpha B-crystallin的表达情况。结果 Alpha B-crystallin mRNA在肺鳞状细胞癌患者癌组织中表达的阳性率显著高于其在癌旁相对正常组织中的表达阳性率(P<0.01),在有淋巴结转移患者癌组织中表达的阳性率明显高于其在无淋巴结转移患者癌组织中的表达阳性率(P<0.05),在较大肿瘤者中的表达阳性率明显高于其在较小肿瘤中的表达(P<0.05),但与患者的性别、年龄以及肿瘤的分化程度无关(P>0.05)。结论 Alpha B-crystallin在肺鳞状细胞癌组织中的高表达可能与肺鳞状细胞癌的发生、发展及侵袭转移相关。
Objective To investigate the expression of Alpha B-crystallin in lung squamous cell carcinoma and its significance. Methods The expression of Alpha B-crystallin was detected by RT-PCR in 44 cases of squamous cell carcinoma of the lung and its adjacent normal tissues. Results The positive rate of Alpha B-crystallin mRNA expression in lung squamous cell carcinoma tissues was significantly higher than that in normal adjacent tissues (P <0.01), and was significantly higher in cancerous tissues with lymph node metastasis (P <0.05), and the positive rate in the large tumor was significantly higher than that in the small tumor (P <0.05), the positive rate was significantly higher than that in the non-lymph node metastasis ), But not with the patient’s gender, age and tumor differentiation (P> 0.05). Conclusion The high expression of Alpha B-crystallin in squamous cell lung cancer may be related to the occurrence, development and invasion and metastasis of squamous cell lung cancer.