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通过电沉积工艺在生物材料Mg-4.0Zn-2.5Sr合金表面制备HA涂层,对比研究了HA涂层与无涂层Mg-4.0Zn-2.5Sr合金在Hank’s溶液中的降解性能及生物相容性。结果表明:通过电沉积工艺电压5 V,温度50℃,时间2 h后,再经过后碱热处理2 h可制备出组织细小、致密、均匀并与基体有良好结合的HA涂层。Mg-4.0Zn-2.5Sr合金在Hank’s溶液中的最终腐蚀速率为0.264 g/(cm~2·h)。HA涂层Mg-4.0Zn-2.5Sr合金在Hank’s溶液中最终腐蚀速率为0.163 g/(cm~2·h)。电化学分析发现HA涂层Mg-4.0Zn-2.5Sr合金的腐蚀电位是-0.801 V,明显高于无涂层Mg-4.0Zn-2.5Sr合金的腐蚀电位-1.33 V,说明经过HA涂层后镁合金的抗腐蚀性能获得提高。HA涂层与无涂层Mg-4.0Zn-2.5Sr合金的细胞溶血率均在生物材料<5%的允许范围之内,作为生物材料使用时均不会发生溶血现象。HA涂层与无涂层Mg-4.0Zn-2.5Sr合金的细胞增殖率均超过96%,为1级细胞毒性,通过细胞形貌特性分析也证明了二者的细胞毒性作用非常小,满足生物材料细胞毒性的要求。
The HA coating was prepared on the surface of biomaterial Mg-4.0Zn-2.5Sr by electrodeposition process. The degradation performance and biocompatibility of HA coating and uncoated Mg-4.0Zn-2.5Sr alloy in Hank’s solution were compared. Sex. The results show that the HA coating with fine structure, dense and uniform structure and good bonding with the matrix can be prepared by the electrodeposition process at 5 V, 50 ℃ and 2 h, and then after alkali treatment for 2 h. The final corrosion rate of Mg-4.0Zn-2.5Sr alloy in Hank’s solution is 0.264 g / (cm ~ 2 · h). The final corrosion rate of HA-coated Mg-4.0Zn-2.5Sr alloy in Hank’s solution was 0.163 g / (cm ~ 2 · h). Electrochemical analysis showed that the corrosion potential of HA-coated Mg-4.0Zn-2.5Sr alloy was -0.801 V, which was significantly higher than that of uncoated Mg-4.0Zn-2.5Sr alloy, which was -1.33 V, indicating that after HA coating The corrosion resistance of magnesium alloy is improved. The hemolysis rates of HA coating and uncoated Mg-4.0Zn-2.5Sr alloy are all within the allowable range of biological material <5%, and do not occur hemolysis when used as biological material. HA coating and uncoated Mg-4.0Zn-2.5Sr alloy cell proliferation rate of more than 96%, a class of cytotoxicity, cell morphology by the analysis also proved that the two cytotoxicity is very small, to meet the biological Material cytotoxicity requirements.