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高效抗逆转录病毒疗法(HAART)可以显著改变HIV-1的感染过程,使发病率和病死率明显降低,但是其不良反应和长期毒性是一个十分严重的问题。这些毒性反应主要与线粒体有关。细胞凋亡生化途径分析显示,线粒体是该途径的主要敏感位点。本文主要讨论了使用核苷类逆转录酶抑制剂(NRTI)和蛋白酶抑制剂后线粒体损害的调节,特别是相关的分子机制。
Highly active antiretroviral therapy (HAART) can significantly alter the course of HIV-1 infection, resulting in a significant reduction in morbidity and mortality but its adverse effects and long-term toxicity are a serious problem. These toxic reactions are mainly related to mitochondria. Analysis of apoptotic biochemical pathways revealed that mitochondria are the major sensitive sites for this pathway. This article focuses on the regulation of mitochondrial damage after use of nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors, and in particular the molecular mechanisms involved.