Chalcone analogue as potent anti-malarial compounds against Plasmodium falciparum:Synthesis,biologic

• 作 者: Jufrizal Syahri Emmy Yuanita B
• 机 构: DepartmentofChemistry,DepartmentofChemistry,DepartmentofChemistry
• 出 处: 亚太热带生物医学杂志：英文版
• 发表日期: 2017年8期
• 关键词: 抗疟药 CHALCONE 停靠 变形体 falciparum 3D7 Antimalarial Chalcone Docking Plasmodium falc
• 基金项目: Ministry of Research,Technology,and Higher Education-Indonesia for the financial support of this work through Hibah Penelitian Disertasi Doktor (PDD)T.A 2017

Objective: To investigate in vitro antimalarial activity of chalcone derivative compounds against Plasmodum falciparum 3D7（Pf3D7） strain and in silico antimalarial activity.Methods: Synthesis of the chalcone derivatives was conducted via Claisen-Schmidt m