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目的对铜绿假单胞菌的临床分布及耐药情况进行分析,从而使得临床使用抗菌药物时有所依据。方法回顾性分析本院重症加强护理病房(ICU)856株铜绿假单胞菌的临床分布及耐药情况。对菌株使用ATBG-5全自动微生物分析仪进行药敏检测和鉴定,使用WHONET软件分析药敏结果。结果 2014年和2015年本院分别检出353株、503株铜绿假单胞菌,其检出率分别为29.0%,36.6%。856株铜绿假单胞菌的检出率痰液检出率最高为63.2%,伤口分泌物检出率第二为20.2%,。复方新诺明、舒巴坦或氨苄西林为抗菌药物中耐药率最高的,其耐药率均高于90%;对妥布霉素、阿米卡星、他唑巴坦或对哌拉西林的耐药率低于16%;美罗培南和亚胺培南具有较大的耐药率增长幅度;铜绿假单胞菌泛耐药菌株检出率为9%。结论应该对监测铜绿假单胞菌耐药性的工作进行重视,对耐药菌株的超视能进行降低和预防。
Objective To analyze the clinical distribution and drug resistance of Pseudomonas aeruginosa so that it can be used for clinical use of antimicrobial agents. Methods The clinical distribution and drug resistance of 856 Pseudomonas aeruginosa in intensive care unit (ICU) in our hospital were retrospectively analyzed. Susceptibility testing and identification of strains using the ATBG-5 automated microbiological analyzer were performed using the WHONET software to analyze susceptibility results. Results 353 and 503 Pseudomonas aeruginosa strains were detected in our hospital in 2014 and 2015, respectively. The detection rates were 29.0% and 36.6% respectively. The detection rate of 856 Pseudomonas aeruginosa sputum was the highest detection rate of 63.2%, the second detection rate of wound secretions was 20.2%. The combination of cotrimoxazole, sulbactam or ampicillin was the most resistant to antibacterials, and its resistance rate was higher than 90%. For tobramycin, amikacin, tazobactam, The resistance rate of Xilin was less than 16%. Meropenem and imipenem had a greater rate of resistance increase. The detection rate of pan-resistant strains of Pseudomonas aeruginosa was 9%. Conclusion It is important to monitor the drug resistance of Pseudomonas aeruginosa and to reduce and prevent the over-visual energy of drug-resistant strains.