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目的观察激素联合受体激动剂吸入治疗小儿哮喘的临床疗效。方法选取2013年2月—2015年6月就诊的哮喘患儿70例,随机分为观察组和对照组各35例。对照组患儿给予单纯的激素吸入法治疗,观察组患儿给予激素联合受体激动剂吸入治疗,均连续治疗3个月。统计两组患儿症状、体征消失时间及住院时间;治疗结束后评价两组疗效;统计两组治疗期间药物不良反应。计量资料用t检验,计数资料用χ2检验,P<0.05为差异有统计学意义。结果观察组哮喘消失时间(3.1±1.2)d、肺部啰音消失时间(4.7±1.1)d、咳嗽消失时间(4.1±1.2)d及住院时间(5.1±1.5)d均明显比对照组(5.2±1.1)、(6.7±1.5)、(5.7±1.4)、(7.2±1.2)d缩短,比较差异有统计学意义(均P<0.05)。观察组治疗总有效率为94.29%,明显高于对照组的74.29%,差异有统计学意义(P<0.05)。观察组不良反应发生率为11.43%,对照组为42.86%,两组比较差异有统计学意义(P<0.05)。结论激素联合受体激动剂吸入治疗小儿哮喘,可快速有效缓解症状,缩短治疗时间,减少不良反应的发生。
Objective To observe the clinical effect of inhaled hormones combined with receptor agonists on pediatric asthma. Methods Seventy patients with asthma admitted from February 2013 to June 2015 were randomly divided into observation group (35 cases) and control group (35 cases). The control group of children given simple hormone inhalation therapy, observation group of children given hormone combined receptor agonist inhalation therapy, were treated for 3 months. The symptoms and signs disappeared and the length of stay in the two groups were counted. After the treatment, the curative effect of both groups was evaluated. The adverse reactions of the two groups were statistically analyzed. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The asthma disappearance time (3.1 ± 1.2) days, pulmonary rales disappearance time (4.7 ± 1.1) days, cough disappearance time (4.1 ± 1.2 days) and hospitalization time (5.1 ± 1.5) days in observation group were significantly higher than those in control group 5.2 ± 1.1), (6.7 ± 1.5), (5.7 ± 1.4) and (7.2 ± 1.2) d, respectively. The difference was statistically significant (all P <0.05). The total effective rate of the observation group was 94.29%, which was significantly higher than that of the control group (74.29%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 11.43% and in the control group was 42.86%, the difference between the two groups was statistically significant (P <0.05). Conclusion Hormone combined with receptor agonist inhalation in children with asthma can quickly and effectively alleviate the symptoms, shorten the treatment time and reduce the incidence of adverse reactions.