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目的观察研究E-cadherin对晚期食管癌化疗有效性的预测作用。方法回顾性分析41例接受化疗的晚期食管癌患者,免疫组化方法检测患者肿瘤组织E-cadherin的表达,分析患者临床病理特征及对化疗的有效性,比较E-cadherin表达与食管癌化疗有效性的关系。结果 41例食管癌患者E-cadherin阳性20例(48.8%),化疗完全缓解(CR)、部分缓解(PR)、稳定(SD)和进展(PD)的病人分别为2例(4.9%)、24例(58.5%)、11例(26.8%)和4例(9.8%),总有效率63.4%,总控制率90.2%。E-cadherin阴性表达较阳性表达,化疗有效率明显降低(P<0.05)。结论食管癌组织E-cadherin阴性表达的患者化疗有效率明显下降,E-cadherin可作为化疗有效率预测的潜在指标。
Objective To observe the predictive value of E-cadherin on the efficacy of chemotherapy in advanced esophageal cancer. Methods The clinical data of 41 patients with advanced esophageal cancer undergoing chemotherapy were retrospectively analyzed. The expression of E-cadherin in the tumor tissue was detected by immunohistochemistry. The clinicopathological features and the effectiveness of chemotherapy were analyzed. The E-cadherin expression was compared with that of esophageal cancer chemotherapy Sexual relations. Results E-cadherin was positive in 20 patients (48.8%), complete response (CR), partial response (PR), stable (SD) and progress (PD) in 41 patients with esophageal cancer. 24 cases (58.5%), 11 cases (26.8%) and 4 cases (9.8%). The total effective rate was 63.4% and the total control rate was 90.2%. E-cadherin negative expression was more positive expression of chemotherapy was significantly lower effective rate (P lt; 0.05). Conclusion The effective rate of chemotherapy in patients with negative E-cadherin expression in esophageal cancer was significantly decreased, and E-cadherin could be used as a potential indicator for predicting the effective rate of chemotherapy.