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目的:了解2007年、2008年及2009年3年河南省局部地区结核分枝杆菌耐药状况,分析耐药趋势及相关的影响因素,为制定耐药(Drug Resistant DR)及耐多药(Multidrug Desistant MDR)病例的管理及治疗方案提供依据。方法:应用连续入选的方法对2007年至2009年我省6个点的涂阳病例进行培养,培养阳性的菌株采用WHO推荐使用的比例法进行一线4种药物的药敏试验。结果:2007年至2009年共入选409例,初治161例,复治348例。其中139例为MDR菌株,MDR-TB年龄分布特点为:16岁～39岁年龄组MDR 46例,40岁～49岁年龄组MDR 40例,50岁～59岁年龄组MDR 31例,?60岁年龄组MDR 22例;性别分布特点:在MDR-TB病人中,男101例,女38例。结论:河南省结核病患者耐药尤其是耐多药状况仍然严重,应加强耐药结核的监测和有效治疗。
OBJECTIVE: To understand the drug resistance of Mycobacterium tuberculosis in some areas of Henan Province in 2007, 2008 and 2009, to analyze the trend of drug resistance and its related factors, to establish a new drug-resistant DR and Multidrug Desistant MDR) case management and treatment programs provide the basis. Methods: Six consecutive smear-positive cases from 2007 to 2009 in our province were cultured. The positive strains were cultured and tested according to the proportion method recommended by the WHO for the first-line drug susceptibility testing. Results: A total of 409 patients were recruited from 2007 to 2009, including 161 newly diagnosed patients and 348 relapsed patients. Among them, 139 cases were MDR strains. The characteristics of age distribution of MDR-TB were 46 cases of MDR in 16-39 year old group, 40 cases of MDR in 40-49 year old group and 31 cases of MDR in 50-59 year old group 22 cases of MDR in the age group; gender distribution characteristics: MDR-TB patients, 101 males and 38 females. Conclusion: The drug resistance of TB patients in Henan Province, especially MDR status, is still serious. Drug-resistant TB should be monitored and effectively treated.