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目的 :观察心肌缺血预适应 (IPC)对急性心肌梗死 (AMI)患者并发症及预后的影响。方法 :对照分析 40例无 IPC的 AMI患者 (A组 )和 5 0例有 IPC的 AMI患者 (B组 )的近期临床资料。结果 :B组梗死后泵功能障碍发生率及程度、磷酸肌酸激酶 (CPK)峰值、并发症均显著低于 A组 ,近期预后有改善。结论 :缺血预适应组 CPK的峰值降低 ,梗死后所致心肌坏死面积减小 ,从而使泵功能障碍的发生率降低、梗死后室性心律失常、 度以上房室传导阻滞及再灌注性心律失常发生率减少。这可能是 IPC使 AMI患者死亡率降低的主要原因。
Objective: To observe the effect of myocardial ischemic preconditioning (IPC) on the complication and prognosis of patients with acute myocardial infarction (AMI). Methods: The clinical data of 40 AMI patients without IPC (group A) and 50 AMI patients with IPC (group B) were compared and analyzed. Results: The incidence and extent of post-infarction pump dysfunction, the peak value of creatine phosphokinase (CPK) and complications in group B were significantly lower than those in group A, and the prognosis was improved in the short term. Conclusions: The peak value of CPK in ischemic preconditioning group decreases, and the area of myocardial necrosis caused by infarction decreases. The incidence of pump dysfunction is reduced, ventricular arrhythmia after infarction, degree of atrioventricular block and reperfusion Arrhythmia incidence decreased. This may be the main reason why IPC reduces the mortality rate of AMI patients.