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目的:探讨自拟方剂联合西医对妊娠期肝内胆汁淤积症患者的疗效及肝功能的影响,为临床诊断治疗提供依据。方法:选择2011年5月—2013年7月的妊娠期肝内胆汁淤积症患者142例,按照随机数字表法将142例患者随机分为对照组与治疗组,各71例;对照组采用西医治疗,治疗组在对照组基础上服用自拟方剂,两组患者治疗均以14 d为1个疗程。结果:治疗组治疗后瘙痒评分(1.04±0.35)显著低于对照组治疗后(1.89±0.38),且有显著性差异(P<0.05);治疗组治疗后AST、TBA、ALT、TBiL值显著低于对照组,且有显著性差异(P<0.05);两组妊娠结局结果比较有显著性差异(P<0.05)。结论:自拟方剂联合西医对妊娠期肝内胆汁淤积症患者疗效明显且安全可靠,具有重要临床研究价值。
Objective: To investigate the effect of self-made prescription combined with western medicine on the efficacy and hepatic function of patients with intrahepatic cholestasis of pregnancy, and provide the basis for clinical diagnosis and treatment. Methods: From May 2011 to July 2013, 142 patients with intrahepatic cholestasis of pregnancy were selected. 142 patients were randomly divided into control group and treatment group according to random number table method, 71 cases in each group. The control group received western medicine Treatment, treatment group on the basis of the control group taking self-prescription, two groups of patients were treated for 14 days for a course of treatment. Results: The score of pruritus in the treatment group (1.04 ± 0.35) was significantly lower than that in the control group (1.89 ± 0.38) (P <0.05), and the levels of AST, TBA, ALT and TBiL in the treatment group were significantly higher Lower than the control group, and there was a significant difference (P <0.05). There were significant differences in pregnancy outcomes between the two groups (P <0.05). Conclusion: The proposed prescription combined with Western medicine in patients with intrahepatic cholestasis of pregnancy obvious and safe and reliable, has important clinical research value.