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目的 探讨严重急性呼吸综合征(SARS)合并急性呼吸窘迫综合征(ARDS)的发病情况、治疗、预后及影响预后的因素。方法 回顾性分析25例SARS合并ARDS患者的临床资料。结果 25例SARS合并ARDS患者的病死率为32％;缺氧(PaO_2<60 mmHg或SpO_2<93％)时间>1d的病死率显著增高(P<0.05);发生4个或以上器官功能障碍的病死率显著增高(P<0.05)。治疗以机械通气、糖皮质激素、抗生素、器官功能维护为主。结论 以及时纠正缺氧、防治MODS的发生为主的综合治疗可望降低病死率。
Objective To investigate the incidence, treatment, prognosis and prognostic factors of severe acute respiratory syndrome (SARS) complicated with acute respiratory distress syndrome (ARDS). Methods The clinical data of 25 SARS patients with ARDS were retrospectively analyzed. Results The mortality of 25 patients with SARS complicated with ARDS was 32%. The mortality of patients with hypoxia (PaO_2 <60 mmHg or SpO_2 <93%) was significantly higher than that of patients with ARDS (P <0.05). There were 4 or more cases of organ dysfunction The case fatality rate was significantly higher (P <0.05). Treatment with mechanical ventilation, glucocorticoid, antibiotics, organ function maintenance based. Conclusions It is expected to reduce the case fatality rate with the comprehensive treatment of timely correcting hypoxia and preventing and treating MODS.