论文部分内容阅读
本实验通过在正常及急性失血大鼠下丘脑外侧区（ＬＨ）注射人参单体皂甙Ｒｂ＿１（Ｒｂ＿１），以血压为指标，探讨了Ｒｂ＿１的中枢性抗应激作用及其机理。在正常大鼠ＬＨ注射Ｒｂ＿１μｇ，其平均动脉压（ＭＡＰ）明显升高。在急性失血造成急性应激状态的大鼠，ＬＨ注射Ｒｂ＿１６μｇ后，其ＭＡＰ上升程度显著高于正常给药组。同时血浆皮质醇测定结果显示，给Ｒｂ＿１组明显高于对照组，而预先注射地塞米松后ＬＨ注射Ｒｂ＿１则不再引起急性失血大鼠血压升高。提示ＬＨ注射Ｒｂ＿１有明显的抗应激作用。
In this study, Rb 1 was injected into the lateral hypothalamic area (LH) of normal and acute hemorrhagic rats to investigate the central anti-stress effect of Rb 1 and its mechanism. In normal rats, Rb_1μg was injected into the LH, mean arterial pressure (MAP) increased significantly. In the acute state of acute blood loss caused by acute stress rats, LH injection of Rb_16μg, MAP increased significantly higher than the normal group. At the same time, the results of plasma cortisol test showed that the Rb_1 group was significantly higher than the control group, while the Rb_1 injection of dexamethasone after pre-injection of dexamethasone did not cause the increase of blood pressure in acute hemorrhagic rats. Prompt LH injection of Rb_1 obvious anti-stress effect.