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目的：探讨兰索拉唑治疗胃食管反流病（ＧＥＲＤ）的效果及维持用药的方法。方法：７０例ＧＥＲＤ随机分为两组，兰索拉唑（Ｌ）组４０例，第１至４周口服兰索拉唑３０ｍｇ每日１次，第５至１２周改为隔日１次，雷尼替丁（Ｒ）组３０例，治疗用雷尼替丁１５０ｍｇ每日２次加西沙必利５ｍｇ每日３次口服，维持用药则单用雷尼替丁。观察两组治疗前后症状评分及食管２４小时ｐＨ监测结果。结果：Ｌ组治疗阶段各周末症状评分依次下降（Ｐ＜０．０５），且分别低于Ｒ组（Ｐ＜０．０５），Ｒ组用药后第２、第３及第４周末之间的症状评分差异不大（Ｐ＞０．０５）。而第４周末和第５周末症状评分差异有显著意义（Ｐ＜０．０５）。Ｌ组第４、第８和第１２周末症状完全缓解率分别为９５％、９３％和９０％，分别高于Ｒ组的８３％、５０％和３７％。第１２周末食管２４小时ｐＨ监测复查结果显示：治后两组食管酸暴露各项指标均有改善，Ｌ组的改善比Ｒ组更为明显，Ｌ组的酸反流总计分９５％（３８／４０）恢复正常（少于１４分），高于Ｒ组的４０％（１２／３０）（Ｐ＜０．０５）。Ｌ组食管炎１１例于第１２周末均痊愈，而Ｒ组１０例只痊愈５例。结论：与雷尼替丁加西沙必利疗法比较，兰索拉唑治疗ＧＥＲＤ具有症?
Objective: To investigate the effect of lansoprazole in the treatment of gastroesophageal reflux disease (GERD) and to maintain the method. Methods: 70 cases of GERD were randomly divided into two groups, lansoprazole (L) group of 40 cases, the first 4 weeks of oral lansoprazole 30mg once a day, the first 5 to 12 weeks changed to every other day, thunder and thunder Nilotin (R) group 30 cases, treatment with ranitidine 150mg twice daily plus cisapride 5mg orally 3 times a day, while maintaining the drug alone ranitidine. The symptom score and esophageal pH monitoring results before and after treatment were observed in both groups. Results: The symptom scores of each group in the L group were decreased in turn (P <0.05), and were lower than those in the R group (P <0.05). The scores of symptom scores in the L group were lower than those of the R group at the 2nd, 3rd and 4th weekend Symptom score was not significantly different (P> 0.05). However, there was significant difference in symptom score between the 4th weekend and the 5th weekend (P <0.05). The complete remission rates at the 4th, 8th and 12th weekend in group L were 95%, 93% and 90%, respectively, which were higher than 83%, 50% and 37% in group R respectively. The results of 24-hour esophageal pH monitoring at the end of the 12th week showed that the indexes of esophageal acid exposure in both groups were improved after treatment, the improvement in L group was more obvious than that in R group, and the total acid reflux in L group was 95% (38 / 40) returned to normal (less than 14 points), higher than 40% (12/30) in R group (P <0.05). Eleven patients with esophagitis in group L were cured at the end of the twelfth week, while only 10 patients in group R were cured. Conclusion: Compared with ranitidine plus cisapride therapy, lansoprazole treatment of GERD is symptomatic?