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目的 观察艾司洛尔 (esmolol,ESM)在无气管插管刺激的条件下对患者脑血管血流动力学指标(CVDI)、心率 (HR)、血压 (BP)的影响。方法 5 4例患者 ,随机分为A、B两组 ,分别静注ESMlmg/kg、2mg/kg ,于注药前 1min ,注药后 1、5、10min ,检测病人CVDI、HR、BP。结果 A、B两组在注药前后各时点CVDI、体循环血压(BP)的两两比较无统计学差异 (P >0 0 5 ) ;两组相同时机CVDI、BP的两两比较亦均无显著性差异 (P >0 0 5 )。A、B两组注药前后的HR两两比较 ,唯注药前 1min与注药后 1min有显著性差异 (P <0 0 5 ) ,A、B两组同时点的两两比较 ,唯注药后 1min有显著性差异 (P =0 0 17) ,其它时点差异无显著性 (P >0 0 5 )。结论 静注ESMlmg/kg、2mg/kg不对脑血管产生作用、亦不影响体循环血压 ;注药前与注药后 1min有减慢心率的作用 ,静注ESM 2mg/kg作用更明显
Objective To investigate the effects of esmolol (ESM) on cerebrovascular hemodynamics (CVDI), heart rate (HR) and blood pressure (BP) in patients without tracheal intubation. Methods Fifty-four patients were randomly divided into A and B groups. ESMlmg / kg and 2mg / kg were intravenously injected respectively. The patients were injected with CVDI, HR and BP 1 min before injection and 1, 5 and 10 min after injection. Results There was no significant difference in CVDI and BP between the two groups before and after injection (P> 0.05). There was no significant difference in CVDI and BP between the two groups Significant difference (P> 0.05). A, B two groups before and after injection of HR compared to each other, only 1min before injection and 1min after injection there was a significant difference (P <0 05), A, B two groups at the same time point comparison, the only note There was a significant difference at 1 min after treatment (P = 0 0 17), but no significant difference at other time points (P 0 05). Conclusion ESMlmg / kg and 2mg / kg did not exert any effect on cerebrovascular function and did not affect systemic blood pressure. Before and 1 min after injection, there was a decrease in heart rate, and the effect of ESM 2 mg / kg was more pronounced