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类固醇引起高血压是糖皮质激素治疗的严重并发症。本文旨在评价钠潴留、高血容量和肾素血管紧张素系统对类固醇引起高血压的作用,并探讨如何识别易患该类高血压的肾脏病患者.作者对35例血压正常的患者(男17例,女18例,年龄14～48岁)作了研究。其中慢性肾小球肾炎(GN)29例,狼疮性肾炎(LN)6例,患者中27例表现为肾病综合征(NS)。所有患者均作肾活检。给予口服强的松龙0.7～0.8mg/kg/d 治疗,钠摄入量为100～120mmol/d,每天测血压及尿量。于给药前及服药第14、28天分别作血肌酐、肾小球滤过率(GFR)、血浆肾素活性(PRA)、血醛固酮(PA)、尿醛固酮(UA)、尿钠和尿钾测定。并对21例于给药前及服药第28天作血容量测定。
Steroid-induced hypertension is a serious complication of glucocorticoid therapy. This article aims to evaluate the role of sodium retention, high blood volume, and renin-angiotensin system in steroid-induced hypertension, and to explore how to identify patients with kidney disease susceptible to this type of hypertension. The authors evaluated 35 normotensive patients (male 17 cases, 18 females, aged 14 to 48 years) were studied. There were 29 cases of chronic glomerulonephritis (GN) and 6 cases of lupus nephritis (LN). Of them, 27 cases showed nephrotic syndrome (NS). All patients underwent a kidney biopsy. Given oral prednisolone 0.7 ~ 0.8mg / kg / d treatment, sodium intake of 100 ~ 120mmol / d, daily blood pressure and urine output. Serum creatinine, glomerular filtration rate (GFR), plasma renin activity (PRA), serum aldosterone (PA), urinary aldosterone (UA), urine sodium and urine Potassium determination. Twenty-one patients were tested for blood volume before administration and on the 28th day after taking the medicine.