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在临床试验中,对于患晚期乳癌的病人应用重组DNA技术生产的高度纯化的人类白细胞A干扰素,进行了效力和安全性的研究结果,发现一种合并症,即依赖剂量的、可逆的中枢神经系统毒性作用。对于放射、激素或细胞毒药物治疗均无效的10名妇女通过肌肉注射给予大剂量重组白细胞的干扰素12周,观察到所有病人都发生可预见的副作用。在注射干扰素后一小时内,出现了类似流感的症状,体温达40℃,头痛,以后则出现肌痛,持续4天。一星期后,多数病人发生昏睡、厌食及恶心,体重下降。上述症状十分严重,拒食可达一星期,每天昏睡长达20小时。
In clinical trials, efficacy and safety of highly purified human leukocyte A interferon produced by recombinant DNA technology were applied to patients with advanced breast cancer, and a comorbidity, a dose-dependent, reversible central nervous system was found. Neurotoxic effects. Ten women who did not respond to radiation, hormones, or cytotoxic drugs were given intramuscular injections of large doses of recombinant interleukin for 12 weeks. All patients were observed to have predictable side effects. Within one hour after the injection of interferon, there was a flu-like symptom, with a body temperature of 40°C, headache, and myalgia later, for 4 days. After a week, most patients developed lethargy, anorexia and nausea, and lost weight. The above-mentioned symptoms are very serious. They can refuse to eat for up to one week and sleep for up to 20 hours a day.