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自80年代以来,我国各地报道服用节育剂量棉酚后,造成不可逆转的生精障碍。我校自1975年临床采用醋酸棉酚施行男性避孕,迄今共观察随访58例,其中两例停药后,定期检查精液,精子计数持续为零而无任何恢复迹象,兹将结果及经过报告于后。材料与方法两例分别为32岁及40岁健康男性,1975年开始服药,15～30mg/日,两月后生效时累计剂量为1050mg及1192mg,持续用药三年半后停服,总服药时间为44个月,总用药量各为6120mg及8872mg。停药后40～60个月内,连续两年取精液三次检查,精子计数持续为零。后在局麻下钳取睾丸组织进行活检。取出大米粒大睾丸组织数块,除立即取材作电镜观察材料
Since the 1980s, various doses of gossypol have been reported in various parts of China, causing irreversible spermatogenic disorders. Our school since 1975, the clinical use of gossypol acetate in the implementation of male contraception, so far observed a total of 58 cases were followed up, of which two were discontinued, regular semen, sperm count remained zero without any signs of recovery, the results and after the report Rear. Materials and Methods Two cases were healthy males aged 32 years and 40 years, taking medication in 1975, 15 ~ 30mg / day, two months after the entry into force of the cumulative doses of 1050mg and 1192mg, continuous medication after three and a half years to stop taking the total medication time For 44 months, the total dose of 6120mg and 8872mg. Within 40-60 months after discontinuation, the sperm was checked three times for two consecutive years, and the sperm count continued to be zero. After under local anesthesia testicular tissue biopsy. Remove the large pieces of rice tablets large number of testicular tissue, in addition to immediately taken for electron microscopy materials