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目的分析中性粒细胞与淋巴细胞比值(NLR)、超敏C反应蛋白(hs-CRP)与颈动脉狭窄(CAS)的相关性。方法选取医院神经内科具有CAS风险且完成颈部血管彩色多普勒超声(CDUS)的154例患者为研究对象。根据有无CAS分为:狭窄组(n=92)与非狭窄组(n=62);根据狭窄程度分为轻度(n=31)、中重度(n=61)狭窄亚组2个亚组。比较各组一般资料NLR、hs-CRP血清学水平。结果狭窄组患者年龄、WBC、NEU、NLR、hs-CRP、HDL-C水平均高于非狭窄组(P<0.05),且具有高血压病、糖尿病、吸烟、饮酒史的比例高于非狭窄组(P<0.05),LYM水平均低于非狭窄组(P<0.05)。轻度、中重度狭窄亚组患者hs-CRP、NLR水平均高于非狭窄组(P<0.05),且中重度狭窄亚组的hs-CRP、NLR水平均高于轻度狭窄亚组,两两比较差异均有统计学意义(P<0.05)。经多因素Logistic分析可知,年龄、NLR为CAS的独立危险因素,OR及95%CI分别为1.425(1.073～1.892)、21.961(6.612～72.943)。结论NLR是CAS的独立危险因素,而不是hs-CRP,NLR随CAS程度升高,可作为预测颈动脉狭窄程度的指标。
Objective To analyze the correlation between neutrophil and lymphocyte ratio (NLR), high sensitivity C-reactive protein (hs-CRP) and carotid artery stenosis (CAS). Methods A total of 154 patients with CAS risk who underwent cervical vascular color Doppler ultrasound (CDUS) were selected as the study subjects. According to the presence or absence of CAS, the patients were divided into two groups: stenosis group (n = 92) and non-stenosis group (n = 62) group. Serum levels of NLR and hs-CRP were compared between the two groups. Results The patients in the stenosis group had higher WBC, NEU, NLR, hs-CRP and HDL-C levels than those in the non-stenosis group (P <0.05), and had higher rates of hypertension, diabetes, smoking and alcohol consumption than those without stenosis Group (P <0.05), LYM levels were lower than non-stenosis group (P <0.05). The levels of hs-CRP and NLR in mild and moderate-severe subgroup were higher than those in non-stenosis group (P <0.05), and the levels of hs-CRP and NLR in subgroups of moderate and severe stenosis were higher than that of mild stenosis group The differences between the two groups were statistically significant (P <0.05). Logistic regression analysis showed that age and NLR were independent risk factors for CAS. OR and 95% CI were 1.425 (1.073-1.892) and 21.961 (6.612-72.943), respectively. Conclusion NLR is an independent risk factor of CAS, not hs-CRP. NLR increases with the degree of CAS, which can be used as an index to predict the degree of carotid artery stenosis.