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目的研究外周血循环肿瘤细胞(CTC)对初诊非小细胞肺癌(NSCLC)治疗监测和预后的价值。方法选取我院2013-01-2014-06收治的73例初诊NSCLC为研究对象。对比73例患者术前、术后第9天CTC的变化,术前CTC与NSCLC患者TNM分期、病理分化程度、病理组织类型及肿瘤大小之间关系。结果初诊NSCLC患者组术后第9天的外周血CTC水平显著低于术前,差异具有统计学意义,t=6.654,P<0.01;CTC水平随着TNM分期递进而增加(P<0.01),随着肿瘤病理分化程度升高而降低(P<0.01),随着肿瘤大小增加而增加(P<0.01),而与肿瘤组织类型无明显关系(P>0.05);NSCLC外周血术前CTC与CEA水平呈正相关,与CYFRA21-1水平无相关性,r=-0.067,P>0.05。Kaplan-Meier结果显示,CTC≥16.5CU时与NSCLC死亡率相关。结论 CTC是NSCLC治疗监测和预后的有益标志物。
Objective To investigate the value of peripheral blood circulating tumor cells (CTCs) in monitoring and prognosis of newly diagnosed non-small cell lung cancer (NSCLC). Methods 73 cases of newly diagnosed NSCLC admitted to our hospital from January 2013 to June 2014 were selected as the research object. The relationship between preoperative CTC and preoperative CTC and TNM staging, pathological differentiation, histological type and tumor size were compared between preoperative and postoperative 9th day in 73 patients. Results The CTC level of peripheral blood in newly diagnosed NSCLC patients was significantly lower than that before operation on the 9th day (t = 6.654, P <0.01). The levels of CTC increased with the progression of TNM (P <0.01) (P <0.01), but increased with tumor size (P <0.01), but not with tumor type (P> 0.05). Preoperative CTC There was a positive correlation with CEA level and no correlation with CYFRA21-1 level, r = -0.067, P> 0.05. Kaplan-Meier results showed that mortality of NSCLC correlated with CTC≥16.5 CU. Conclusion CTC is a useful marker of NSCLC treatment monitoring and prognosis.