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目的研究孔圣枕中丹及其拆方对小鼠的抗焦虑作用。方法正交试验设计,采用高架十字迷路模型观察灌胃给予孔圣枕中丹及其拆方对小鼠抗焦虑作用;地西泮作为平行对照。结果孔圣枕中丹及其拆方有增加入开臂次数和入开臂时间趋势;与空白对照组相比,地西泮和实验5(远志2g/kg,石菖蒲2g/kg,龙骨2g/kg)延长入开臂时间和开臂时间百分比具有显著差异;正交分析,抗焦虑作用的活性顺序是:远志>石菖蒲>龙骨>龟板,方差分析远志差异显著。结论孔圣枕中丹具有较弱的抗焦虑作用。
Objective To study the anti-anxiety effect of Zhongshen Pill and its decomposed formulas in mice. Methods Orthogonal experiment design was used to observe the anxiolytic effect of Zhongdan Pill and its disassembled prescriptions on the mice by intragastric administration with elevated cross-labyrinth model. Diazepam was used as a parallel control. Results Compared with blank control group, Diazepam and experimental group 5 (Polygala 2g / kg, Acorus gram 2g / kg, keel 2g / kg) had a significant difference in the percentage of open arm opening time and arm opening time. The order of activities of orthogonal analysis and anti-anxiety was Polygala tenuifolia> Acorus calamus> Keel> turtle shell and variance analysis. Conclusions Kong Sheng pillow pill has a weaker anti-anxiety effect.