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目的评价EOF方案和FOLFOX4方案治疗晚期胃癌的近期疗效和不良反应。方法 70例晚期胃癌随机分为EOF组和FOLFOX4组,EOF组采用草酸铂130mg/m2,静脉滴注2h,d1;亚叶酸钙200mg/m2,静脉滴注2h,d1～5;5-氟尿嘧啶500mg/(m2.d),持续静脉输注120h;表阿霉素50mg/m2,静脉滴注,第6d给予,21d为1周期,3周期后评价疗效。FOLFOX4组采用草酸铂85mg/m2,静脉滴注,d1;亚叶酸钙200mg/m2,静脉滴注2h,d1～2;其后5-氟尿嘧啶400mg/m2,静脉推注,d1～2,接着5-氟尿嘧啶600mg/m2持续静脉输注22h,14d为1周期,4个周期后评价疗效。结果两组近期有效率EOF组53.3%,FOLFOX 4组48.6%,两组比较无统计学差异,不良反应比较有统计学意义。结论 EOF方案与FOLFOX方案治疗晚期胃癌均有效,不良反应不同。
Objective To evaluate the short-term efficacy and side effects of EOF and FOLFOX4 in the treatment of advanced gastric cancer. Methods Seventy patients with advanced gastric cancer were randomly divided into EOF group and FOLFOX4 group. EOF group was treated with oxaliplatin 130mg / m2, intravenous drip 2h, d1; leucovorin 200mg / m2, intravenous drip 2h, d1-5; /(m2.d), continuous intravenous infusion of 120h; epirubicin 50mg / m2, intravenous infusion, given on the 6th, 21d for the 1 cycle, 3 cycles after the evaluation of the effect. FOLFOX4 group with oxaliplatin 85mg / m2, intravenous infusion, d1; leucovorin 200mg / m2, intravenous infusion 2h, d1 ~ 2; followed by 5- fluorouracil 400mg / m2, intravenous injection, d1 ~ 2, followed by 5 - fluorouracil 600mg / m2 continuous intravenous infusion of 22h, 14d for the 1 cycle, 4 cycles after the evaluation of efficacy. Results The effective rate of the two groups was 53.3% in the EOF group and 48.6% in the FOLFOX 4 group. There was no significant difference between the two groups, and the adverse reactions were statistically significant. Conclusion Both EOF and FOLFOX regimens are effective in treating advanced gastric cancer with different adverse reactions.