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研究目的 探讨抗癫痫药物对小儿骨代谢的影响。 研究设计 病例对照研究。 患者和其它参与者 长期服抗癫痫药物患儿20例(AEDs组),服药时间最长者6年,最短者0.5年。初诊癫痫尚未开始服药的15名患者为非AEDs组。30名健康儿童为正常对照组。 测定方法 AKP、骨型酸性磷酸酶(TR-ACP)分别用 Kind-King 改良法及 Bessey-Lowry法。血钙、磷测定用400E型自动生化分析仪。 结果 ADEs组、非ADEs组和正常对照组AKP活性分别为190±47、144±38和1.43±40IU/L,前者分别与后两者相比均有显著性差异(P<0.05)。AKP活性>200IU/L者占55％,低钙、低磷均占10％。TR-ACP活性、Ca、P含量组间无显著性差异。 结论 服用抗癫痫药对儿童骨代谢有一定影响。
Objective To investigate the effect of antiepileptic drugs on bone metabolism in children. Study design Case-control study. 20 patients (AEDs group) with long-term anti-epileptic drugs were the patients and other participants. The longest time was 6 years and the shortest was 0.5 years. Fifteen patients with newly diagnosed epilepsy who had not started taking the medication were non-AEDs. 30 healthy children as normal control group. Determination of AKP, bone acid phosphatase (TR-ACP) were Kind-King improved method and Bessey-Lowry method. Calcium, phosphorus determination with 400E automatic biochemical analyzer. Results The AKP activities of ADEs group, non-ADEs group and normal control group were 190 ± 47, 144 ± 38 and 1.43 ± 40 IU / L, respectively. There was significant difference between the former and the latter two groups (P <0.05). AKP activity> 200IU / L accounted for 55%, low calcium, low phosphorus accounted for 10%. TR-ACP activity, Ca, P content between the groups no significant difference. Conclusion Anti-epileptic drugs have some effect on bone metabolism in children.