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由于耐药恶性疟原虫类蔓延给无并发症和恶性疟原虫所致严重疟疾的治疗增加了困难。血中不同发育期的微小间日疟原虫、卵形疟原虫和三日疟原虫仍对4-氨基喹诺酮、磺胺类和二氨基嘧啶以及二者联用均敏感。在抗疟疾化疗中,奎宁已使用了三百多年,而且在体外对恶性疟原虫仍显示有效,但是奎宁的毒性限制了它的使用。由于采用的10天标准疗法导致了药物顺应性以及副作用的频繁发生,造成了对奎宁治疗的不满。最近10年间集中深入研究并发展了抗耐药疟原虫
The difficulties have been exacerbated by the spread of resistant Plasmodium falciparum to the treatment of severe malaria without complications and Plasmodium falciparum. Plasmodium vivax, Plasmodium ovale and Plasmodium malariae at different developmental stages of the blood are still sensitive to 4-aminoquinolones, sulfonamides and diamino-pyrimidines, and to both. In anti-malarial chemotherapy, quinine has been used for over three hundred years and remains effective against P. falciparum in vitro, but the toxicity of quinine has limited its use. The 10-day standard therapy used led to frequent drug compliance and side effects, creating dissatisfaction with quinine therapy. In the recent 10 years, intensive study and development of resistant Plasmodium