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氯丙嗪于1950年由Charpentier氏合成,两年后法国的Delay和Deniker二氏用于精神科临床,并报道了本药治疗精神病的效果。自1954年起,在欧美有大量的文献报道。我国有关氯丙嗪治疗精神疾病的报道见于1956年,迄今已有30年的临床经验。今将抗精神病药的临床应用概况,扼要综述如下。一、几类药物 1.吩噻嗪类药物在所有的抗精神病药中,氯丙嗪是应用时间最长和报道较多的一种。在开始应用的6年中,主要是观察该药的临床疗效、适宜的剂量和
Chlorpromazine was synthesized by Charpentier in 1950 and two years later French Delay and Deniker II were used in psychiatric clinics and reported the effect of the drug in the treatment of psychosis. Since 1954, there are a large number of reports in Europe and the United States. China’s report on chlorpromazine in the treatment of mental illness was found in 1956, so far, it has 30 years of clinical experience. The clinical application of antipsychotic profile, briefly summarized below. First, several types of drugs 1. Phenothiazines in all antipsychotic drugs, chlorpromazine is the longest and reported one more. In the first 6 years of application, the main observation is the clinical efficacy of the drug, the appropriate dose and