山苍子油对大白鼠骨髓细胞染色体畸变的实验研究

• 作 者: 黎七雄 俞平 李立中 张志善 周启达 解梦霞
• 机 构: 湖北医学院药理教研室,湖北医学院药理教研室,湖北医学院药理教研室,湖北医学院药理教研室,湖北医学院生物教研室,湖北医学院生物教研室,
• 出 处: 湖北医学院学报
• 发表日期: 1984年04期
• 关键词: 山苍子油 大白鼠 染色体畸变 致畸作用 细胞染色体 骨髓 染色体断裂 环磷酰胺 山苍子 心肌梗塞范围

本文研究了山苍子油对对大白鼠骨髓细胞染色体的致畸作用。实验分四组。盐水对照组及山苍子油大剂量组(1 ml/kg/天,连服7天)未见畸变细胞。山苍子小剂量组(0.5ml/kg/天,连服7天)虽出现0.6％单体断裂,但未超过自然畸变率。环磷酰胺组(40mg/kg/天,连服5天)畸变率为12.7％,染色体断裂总数为17.7％。结果表明:山苍子油对大白鼠骨髓细胞染色体无致畸作用。

This paper studied the teratogenic effects of Litsea cubeba oil on chromosomes of rat bone marrow cells. The experiment was divided into four groups. Saline control group and Litsea cubeba L. large-dose group (1 ml/kg/day, continuous serving for 7 days) showed no abnormal cells. In the low dose group of Litsea cubeba (0.5ml/kg/day, served for 7 days), although 0.6% of monomer was broken, it did not exceed the natural distortion rate. The rate of aberration in the cyclophosphamide group (40 mg/kg/day for 5 days) was 12.7%, and the total number of chromosomal breaks was 17.7%. The results showed that Litsea cubeba oil had no teratogenic effects on the chromosome of rat bone marrow cells.