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人工合成的雌激素和孕激素是从1957年作为避孕药而被广泛使用。当时,这些甾体激素与血压之间的关系人们还不了解。1962年,Brownrigg首次报导,一位患子宫内膜异位症的妇女使用异炔诺酮(剂量从10mg/天增至40mg/天)治疗6个月后,血压由120/80mmHg上升至200/100mmHg,并伴有头痛、体重增加等症状。1966年,Owen也发现一名妇女使用Enovid(含异炔诺酮5mg,乙炔雌二醇三甲醚0.75mg)避孕后,产生高血压。因此,在一些国家开始了观察
Synthetic estrogen and progestin are widely used as contraceptives from 1957. At the time, the relationship between these steroids and blood pressure was not understood. In 1962, Brownrigg first reported that a woman with endometriosis increased blood pressure from 120 / 80mmHg to 200 / 80mmHg after 6-month treatment with norethindrone (10mg / day to 40mg / day) 100mmHg, accompanied by headache, weight gain and other symptoms. In 1966, Owen also found that a woman developed hypertension after using contraceptive Enovid (norethindrone 5 mg, ethinyl estradiol, trimethylether 0.75 mg). Therefore, some countries started the observation