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丁胺卡那霉素(Amilacin)对革兰氏阴性菌有效,可制成注射剂供临床用。由于潜有中毒危险,给药时应严格地在微生物学的指导下对照使用,其给药方案亦应根据药物代谢动力学的参数来准确制定。本研究的主要目的是确定二种给药途径——肌内注射和静脉注射丁胺卡那霉紊的药物代谢动力学变化。给17例肾功能正常(肌酐清除率大于90ml/分)的病人单次剂量(7.5mg/kg 体重)丁胺卡那霉素,其中
Amilacin is effective against Gram-negative bacteria and can be formulated as an injectable for clinical use. Due to the potential risk of poisoning, administration should be strictly controlled under the guidance of microbiology, and its dosing regimen should be based on pharmacokinetic parameters to accurately develop. The main objective of this study was to determine the pharmacokinetics of the two routes of administration - intramuscular and intravenous amikacin. A single dose (7.5 mg / kg body weight) of amikacin was given to 17 patients with normal renal function (creatinine clearance> 90 ml / min), of which