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磁导向下磁性药物载体的作用机理是在药物微球中加入具有磁响应性的物质(如Fe_3O_4),再将磁性药物注入组织内,同时在肿瘤外部施加有效强度和梯度的外磁场,使磁性药物固定于肿瘤组织内,以达到治疗的目的。 该方法优点突出,主要表现在:(1)可以更有效的减少网状内皮系统(RES)的吸收。(2)磁性药物微球有缓慢释放作用,可以相应地耐受较高的药物剂量,研究表明:应用磁性微球可使有效药物的化疗指数增加10-100倍。(3)加速产生药效,提高疗
The mechanism of the magnetism-guided magnetic drug carrier is to add a magnetically responsive substance (such as Fe 3 O 4 ) into the drug microspheres, then inject the magnetic drug into the tissue, and at the same time apply an external magnetic field of effective intensity and gradient to the outside of the tumor to make the magnetism. The drug is fixed in the tumor tissue for therapeutic purposes. The advantages of this method are outstanding, mainly reflected in: (1) It can reduce the absorption of reticuloendothelial system (RES) more effectively. (2) The magnetic drug microspheres have a slow release effect and can tolerate relatively high drug doses accordingly. Studies have shown that the use of magnetic microspheres can increase the chemotherapeutic index of effective drugs by 10-100 times. (3) Accelerate drug efficacy and improve