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目的 :血管平滑肌细胞 (ＶＳＭＣ)异常增殖 ,血管壁细胞外间质组成改变导致的血管重构 ,在高血压、动脉粥样硬化、血管再狭窄等许多心血管疾病的发病中起重要作用 ,血管紧张素Ⅱ (ＡｎｇⅡ )是肾素 -血管紧张素系统的主要因子 ,显著增加ＶＳＭＣ的增殖和肥大 ,但确切分子机制尚
OBJECTIVE: Vascular remodeling caused by abnormal proliferation of vascular smooth muscle cells (VSMCs) and changes in the extracellular matrix composition of the vascular wall plays an important role in the pathogenesis of many cardiovascular diseases such as hypertension, atherosclerosis and vascular restenosis. Ang II is a major factor in the renin-angiotensin system and significantly increases VSMC proliferation and hypertrophy, but the exact molecular mechanism