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二噁英类化合物既是环境内分泌干扰物,又是一种持久性有机污染物,由于其具有难以降解、可生物累积、可远距离传输等特性,因此无论是接触二噁英作业的职业人群和居住在二噁英排放源周边的居民,还是远离二噁英暴露源的一般人群,都会不同程度的暴露于二噁英的污染。近年来的研究发现,除遗传、生活方式等传统因素之外,环境因素特别是二噁英类化合物身体负荷的增加也增加了患糖尿病的风险,但作用机制尚不明确。笔者将对二噁英影响2型糖尿病发病的流行病学研究进展作简要介绍。
Dioxins are not only environmental endocrine disruptors but also persistent organic pollutants. Due to their characteristics of being difficult to degrade, bioaccumulating and long-distance transmission, dioxin-like compounds are not only the occupational groups exposed to dioxin, Residents living in the vicinity of dioxin-emitting sources, or the general population away from sources of dioxin exposure, will be exposed to varying degrees of dioxin pollution. In recent years, studies have found that in addition to the traditional factors such as inheritance and lifestyle, the increase of environmental burden, especially the body burden of dioxin-like compounds, also increases the risk of developing diabetes, but the mechanism of action is not yet clear. I will dioxins affect the incidence of type 2 diabetes epidemiological research briefing.